trouble with biomarkers and press releases

The latest issue of the Journal of Neuroscience contains an interesting article by Ecker et al in which the authors attempted to classify people with autism spectrum disorder (ASD) and health controls based on their brain anatomy, and report achieving “a sensitivity and specificity of up to 90% and 80%, respectively.” Before unpacking what that … Continue reading trouble with biomarkers and press releases

specificity statistics for ROI analyses: a simple proposal

The brain is a big place. In the context of fMRI analysis, what that bigness means is that a typical 3D image of the brain might contain anywhere from 50,000 – 200,000 distinct voxels (3D pixels). Any of those voxels could theoretically show meaningful activation in relation to some contrast of interest, so the only … Continue reading specificity statistics for ROI analyses: a simple proposal